• 产品编号: Asc-017
    • 产品名称:CNQX
    • 产品规格:10mg/25mg/50mg
    • 价  格:1230.00/2850.00/5310.00
    • 供 应 商:Ascent
    • 库  存:
  • CNQX

    AMPA / kainate antagonist (AMPA/红藻氨酸拮抗剂)
    Purity: >99%

    Biological Description
    Potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site.

    Useful References
    Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241:701 abstract

    Birch et al (1988) 6,7-Dinitro-quinoxaline-2,3-dione and 6-nitro,7-cyano-quinoxaline-2,3-dione antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor. Eur.J.Pharmacol. 156:177 abstract

    Long et al (1990) Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate- and quisqualate-mediated depolarization of rat motoneurones in vitro. Br.J.Pharmacol.100:850 abstract



    Our products in action...
    Ting et al. (2007) Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms Proc Natl Acad Sci U S A. 104: 353-8 abstract

    Nicoll et al. (2007) TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists. Science 318 :815-7. abstract


    Chemical Information
    6-Cyano-7-nitroquinoxaline-2,3-dione
     

    • Desiccate at +4°C
    • MW 232.16
    • Soluble to 100 mM in DMSO and to 100 mM with 2eq. NaOH
    • C9H4N4O4
    • 115066-14-3