• 产品编号:Asc-018
    • 产品名称:DNQX
    • 产品规格:10mg/50mg
    • 价  格:480.00/1530.00
    • 供 应 商:Ascent
    • 库  存:
  • DNQX

    AMPA / kainate antagonist
    Purity: >99%

    Biological Description
    AMPA / kainate antagonist

    Useful References
    Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241:70. abstract

    Watkins et al (1990) Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of non-NMDA receptors. Adv.Exp.Med.Biol. 268:49 abstract

    Davies and Collingridge (1990) Quinoxalinediones as excitatory amino acid antagonists in the vertebrate central nervous system. Int.Rev.Neurobiol. 32:281 abstract



    Our products in action...
    Ting et al. (2007) Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms Proc Natl Acad Sci U S A. 104: 353-8 abstract

    Ahmed et al. (2009) Mechanisms of Antagonism of the GluR2 AMPA Receptor: Structure and Dynamics of the Complex of Two Willardiine Antagonists with the Glutamate Binding Domain. Biochemistry 48(18):3894-903 abstract


    Chemical Information
    6,7-Dinitroquinoxaline-2,3-dione
     


     

    • Desiccate at +4°C
    • MW 252.14
    • Soluble to 100 mM in DMSO
    • C8H4N4O6
    • 2379-57-9


     

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