• 产品编号:S102
    • 产品名称:Steffimycin B
    • 产品规格:1mg/5mg
    • 价  格:询价
    • 供 应 商:美国TOKU-E
    • 库  存:
  • Description

    Steffimycin B is an anthracycline metabolite isolated from a Streptomyces sp. with antibacterial and antineoplastic properties. Crystallographic studies of binding to DNA suggest that it has a higher CpG base sequence specificity over the TpA step, similar to that of daunorubicin and nogalamycin. A close analogue was shown to be active against ras oncogene-expressed cells.


    Steffimycin B is soluble in ethanol, methanol, DMF and DMSO.

    References

    Molecular structure of antitumor drug steffimycin and modeling of its binding to DNA. Sriram M. et al. J. Biomol. Struct. Dyn. 1991, 9, 251.

    Screening of antibiotics preferentially active against ras oncogene-expressed cells. Suzukake-Tsuchiya K. et al. J. Antibiot. 1990, 43, 1489.

    Steffimycin B, a DNA binding agent. Reusser F. Biochim. Biophys. Acta 1975, 383, 266.

     

    Purity Level

    >99% by HPLC

     

    CAS Number

    54526-94-2

    Molecular Formula

    C29H32O13

    Molecular Weight

    588.6

    Appearance

    Orange Lyophilisate

    Purity Level

    >99% by HPLC

    Storage Conditions

    -20°C

     

    For in vitro research use only. Not suitable for human or animal consumption.

    上一篇:Staurosporine
    下一篇:Sterigmatocystin