• 产品编号:S070
    • 产品名称:Staurosporine
    • 产品规格:5mg/25mg
    • 价  格:询价
    • 供 应 商:美国TOKU-E
    • 库  存:
  • Description

    Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumor active, inducing apoptosis in a variety of cell lines. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.


    Staurosporine is soluble in ethanol, methanol, DMF and DMSO.

    Mechanism of Action

    Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D.

     

    References

    IkappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin. Peet G.W. et al. J. Biol. Chem. 1999, 274, 32655.

    Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines. Boix J. et al. Neuropharmacology 1997, 36, 811.

    Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. Ruegg U.T. et al. Trends Pharmacol. Sci. 1989, 10, 218.

     

    Purity Level

    >99% by HPLC

     

    CAS Number

    62996-74-1

    Molecular Formula

    C28H26N4O3

    Molecular Weight

    466.5

    Appearance

    White solid

    Purity Level

    >99% by HPLC

    Storage Conditions

    -20°C

     

    For in vitro research use only. Not suitable for human or animal consumption.

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