• 产品编号:S101
    • 产品名称:Stauprimide
    • 产品规格:0.5mg/2.5mg
    • 价  格:询价
    • 供 应 商:美国TOKU-E
    • 库  存:
  • Description

    Stauprimide is a semi-synthetic analogue of the staurosporine family of indolocarbazoles. Stauprimide was first published in 1994 as part of an extensive structure-activity investigation to improve the selective inhibition of protein kinase C as potential antitumor agents. Stauprimide increases the efficiency of the directed differentiation of mouse and human embryonic stem cells in synergy with defined extracellular signalling cues.


    Stauprimide is soluble in ethanol, methanol, DMF and DMSO.

    Mechanism of Action

    Stauprimide interacts with NME2 (PUF) transcription factor to down-regulate c-Myc expression, leading to differentiation of stem cells.

     

    References

    Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C. Caravatti G. et al. , Bioorg. Med. Chem. Letters 1994, 4, 399.

    A small molecule primes embryonic stem cells for differentiation. Zhu S. et al. , Cell Stem Cell 2009, 4, 416

     

    Purity Level

    >95% by HPLC

     

    CAS Number

    154589-96-5

    Molecular Formula

    C35H28N4O5

    Molecular Weight

    584.6

    Appearance

    Yellow orange solid

    Purity Level

    >95% by HPLC

    Storage Conditions

    -20°C

     

    For in vitro research use only. Not suitable for human or animal consumption.

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