• 产品编号:S083
    • 产品名称:Siomycin A
    • 产品规格:0.5mg/2.5mg
    • 价  格:询价
    • 供 应 商:美国TOKU-E
    • 库  存:
  • Description

    Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity discovered in 1969. Siomycin is a potent inhibitor of the oncogenic transcription factor, FoxM1. The reduced transcription activity is reflected in the down regulation of protein and mRNA levels of FoxM1 and effects on down stream genes, Cdc25B, survivin and CENPB. In vitro, siomycin inhibits FoxM1-induced cell growth on soft agar and selectively kills transformed but not normal cells.


    Siomycin is soluble in DMF and DMSO.

     

    References

    Studies on Siomycin. I Physicochemical properties of siomycin A, B and C. Ebata, M. et al. J. Antibiot., Ser. A, 1969, 22, 364.

    Identification of a chemical inhibitor of the oncogenic transcription factor Forkhead Box M1. Radhakrishnan et al. Cancer Res. 2006, 19, 9731.

     

    Purity Level

    >95% by HPLC

     

    CAS Number

    12656-09-6

    Molecular Formula

    C71H81N19O18S5

    Molecular Weight

    1648.9

    Appearance

    White solid

    Purity Level

    >95% by HPLC

    Storage Conditions

    -20°C

     

    For in vitro research use only. Not suitable for human or animal consumption.