• 产品编号:S039
    • 产品名称:Simvastatin
    • 产品规格:25mg/100mg
    • 价  格:询价
    • 供 应 商:美国TOKU-E
    • 库  存:
  • Description

    Simvastatin is semi-synthetic, slightly more hydrophobic analogue of lovastatin. Like lovastatin, simvastatin is a specific inhibitor of HMG-CoA reductase and is used therapeutically to reduce LDL cholesterol. More recently, the statins have become important biochemical probes in cell biology. Their involvement in many events can be correlated to their primary mode of action, however, the mechanism of action of many other effects is less apparent.


    Simvastatin is soluble in ethanol, methanol, DMF and DMSO.

     

    References

    Hoffman W. F. US Patent 4,444,784 (1984).

    Lovastatin and simvastatin are modulators of the proteasome. Wojcik C. et al. Int. J. Biochem. Cell Biol. 2000, 32, 957.

    3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: Implications for diabetic nephropathy. Danesh F. R. et al. Proc. Natl. Acad. Sci. USA 2002, 99, 8301.

    HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. Xu H. et al. Am. J. Physiol. Renal. Physiol. 2006, 291, F995.

     

    Purity Level

    >98% by HPLC

     

    CAS Number

    79902-63-9

    Molecular Formula

    C25H38O5

    Molecular Weight

    418.6

    Appearance

    White powder

    Purity Level

    >98% by HPLC

    Storage Conditions

    -20°C

     

    For in vitro research use only. Not suitable for human or animal consumption.

    上一篇:Siccanin
    下一篇:Sinefungin