• 产品编号:S082
    • 产品名称:Siccanin
    • 产品规格:1mg/5mg
    • 价  格:询价
    • 供 应 商:美国TOKU-E
    • 库  存:
  • Description

    Siccanin is an unusual fused phenolic pentacycle first isolated from Helminthosporium siccans and reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.


    Siccanin is soluble in ethanol, methanol, DMF and DMSO.

     

    Mechanism of Action

    Siccanin inhibits succinate dehydrogenase in the terminal electron transport system.

     

    References

    Studies on antibiotics from Helminthosporium sp. fungi. VII Siccanin, a new antifungal antibiotic produced by Helminthopsporium siccans. Ishibashi K. J. Antibiot. Series A 1962, 15, 161.

    Mode of action of the antibiotic siccanin on intact cells and mitochondria of Trichophyton mentagrophytes. Nose K. & Endo A. J. Bacteriol. 1971, 105, 176.

    Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor. Mogi T.J. et al. Biochem. 2009, 146, 383.

     

    Purity Level

    >98% by HPLC

     

    CAS Number

    22733-60-4

    Molecular Formula

    C22H30O3

    Molecular Weight

    342.5

    Appearance

    White solid

    Purity Level

    >98% by HPLC

    Storage Conditions

    -20°C

     

    For in vitro research use only. Not suitable for human or animal consumption.

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